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PHARMA FORMULATIONS


Pharmaceutical formulations, in pharmaceutics, are the process in which different chemical substances, including the active drug, are combined to produce a final medicinal product. The word formulation is often used in a way that includes dosage form. Formulation studies involve developing a preparation of the drug which is both stable and acceptable to the patient. For orally taken drugs, this usually involves incorporating the drug into a tablet or a capsule. 
It is unlikely that formulation studies will be complete by the time clinical trials commence. This means that simple preparations are developed initially for use in phase I clinical trials. These typically consist of hand-filled capsules containing a small amount of the drug and diluents. Proof of the long-term stability of these formulations is not required, as they will be used (tested) in a matter of days. Consideration has to be given to what is known as "drug loading" - the ratio of the active drug to the total contents of the dose. A low drug load may cause homogeneity problems. A high drug load may pose flow problems or require large capsules if the compound has a low bulk density.
Types of Pharmaceutical Formulations.

• Oral drugs

  • • Parental (Injections) Formulations
  • • Topical Formulations
  • • Modified release Formulations
  • • Novel Drug Formulations
  • • Oncological Formulations

 

 

Finished Formulations

 

Large volume Parenterals (LVPS) -Plastic
Large volume Parenterals (LVPS) –Bags
Large volume Parenterals (LVPS) –Glass

 

Lyophilized Liquid Injections

Non Beta lactum Products –Oral

Penicillin based beta lactum Products

Sterile Injections

 

Nikolos Pharmae